30 Best Menopause Supplements 30 Best Menopause Supplements

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13 minute read Updated on 26th October 2025

30 Best Menopause Supplements

Written by David Letsa, MD
Medically reviewed by Katerina Shkodzik, MD, Ob&Gyn

The journey through perimenopause and menopause can feel like navigating a complex maze of symptoms, and finding relief can feel overwhelming. Menopause is a stage in a woman's life when her menstrual periods stop and her hormone levels decrease. It typically affects women between the ages of 45 and 55, but it can happen earlier. It is important to note that menopause is a natural part of the aging process and signifies the end of a woman's reproductive years. Perimenopause, meaning "around menopause," is the transitional phase leading up to menopause, when a woman's body begins its natural shift toward the end of her reproductive years.

Navigating hormone changes in perimenopause and menopause is a unique journey for every woman. It's a natural biological transition, but it can come with challenging symptoms like hot flashes, night sweats, joint pain, mood swings, and weight gain. While many turn to lifestyle changes or prescription treatments, a growing number of women are exploring a different path – menopause supplements – and other natural menopause relief options.

This guide will walk you through what these supplements are, how they differ from traditional treatments like Hormone Replacement Therapy (HRT) or Menopausal Replacement Therapy, and highlight some of the most popular choices available.

What Are Menopause Supplements and Do They Work?

Menopause supplements are a broad category of products, typically in pill, capsule, or powder form, that contain a variety of vitamins, minerals, and herbal extracts, unlike HRT, which is a prescription medication designed to replace declining hormones directly. Understanding these options can empower women to choose what feels right for their individual needs.

Natural menopause supplements are intended to relieve specific symptoms. They are often marketed as "natural" solutions to help manage hot flashes, support mood, alleviate joint pain, or aid in weight management. Many women also look for supplements for perimenopause to address the irregular periods and early hormonal shifts that characterize this transition.

Supplement effectiveness varies greatly, from scientifically supported to anecdotal, and many lack FDA clinical trials. Individual factors like body chemistry and lifestyle impact results, as does the placebo effect. Always consult a healthcare provider before starting supplements, especially if you have existing medical conditions or are taking other medications. 

Menopause can be a pretty sensitive and challenging experience. One way to feel in control is to track ovulation changes and understand if you have fluctuating estrogen levels. You can do this with the Mira Menopause Transitions Kit and Menopause Transitions Mode in the Mira App, which can help visualize changes with charts and navigate them with confidence. This at-home hormone monitor utilizes AI to track key reproductive hormones and their metabolites in urine, including FSH, LH, PdG (a progesterone metabolite), and E3G (an estrogen metabolite).

Resources such as the Hormone Health Clinic for Fertility can offer essential support and expert guidance customized to your specific needs. These professionals have specialized knowledge about hormonal changes, symptom management, and treatment options.

Supplements vs. Hormone Replacement Therapy (HRT)

Hormone Replacement Therapy (HRT) or Menopausal Replacement Therapy involves using synthetic or bioidentical estrogen and progesterone to directly replace the hormones that the body stops producing during menopause. Many individuals find relief from severe menopausal symptoms through this effective treatment, allowing them to regain a sense of well-being during this transitional phase of life. Supplements do not replace hormones; instead, they contain compounds believed to influence the body’s systems to reduce symptoms.

Feature

Menopause Supplements

Hormone Replacement Therapy (HRT)

Definition

Non-prescription vitamins, herbs, and nutrients intended to relieve menopause symptoms naturally

Prescription treatment using estrogen or a combination of estrogen and progesterone to replace declining hormones

Purpose

Support symptom relief (e.g., hot flashes, sleep, joint pain) without hormones

Treat moderate to severe menopausal symptoms and prevent bone loss by restoring hormone levels

Effectiveness

Mild to moderate symptom relief; varies by supplement and individual

Proven to be highly effective for hot flashes, night sweats, vaginal dryness, and bone loss

Regulation

Not FDA-regulated for efficacy or safety (except individual vitamins/minerals)

FDA-approved and medically supervised

Risks

Generally low risk, but may cause side effects or interact with medications 

Associated with risks like blood clots, stroke, and breast cancer (depends on age, HRT type, and health status)

Use Case

Often preferred by women seeking a natural or hormone-free approach

Recommended for women with severe symptoms who are good candidates based on their medical history

Monitoring

No required medical oversight, but recommended

Requires regular monitoring by a healthcare provider

Best Supplements for Menopause

Navigating the hormonal changes that come with menopause can be challenging, and it's essential to listen to your body rather than make assumptions about what you should do. Many people explore supplements in hopes of finding relief from their symptoms, but approaching these options should be done thoughtfully and based on solid evidence.

This guide is intended to help you understand some of the most commonly discussed supplements for menopause. We’ll talk about their traditional uses, how they work, and what the latest scientific research has to say about their effectiveness. Your journey through this transition is personal, and having reliable information can help you make informed decisions that best suit your needs.

Vitamins for Hot Flashes and Night Sweats

1. Vitamin E

Vitamin E is an antioxidant that may help reduce the frequency of hot flashes. Evidence is mixed; some small-scale studies have shown modest improvement, while larger, more rigorous trials have found limited benefits. This is one of the more common vitamins for menopause that women consider.

2. Vitamin B6 and B12

These B vitamins are essential for nerve function and mood regulation. While there is no direct evidence that they reduce hot flashes, they can help support energy levels and manage mood swings that often accompany menopause and perimenopause. They are among the vitamins for perimenopause that can help with mood and energy.

3. Black Cohosh

One of the most widely used herbal remedies for menopausal symptoms, black cohosh has been studied for its potential to reduce hot flashes and night sweats. Evidence is mixed, with some clinical trials reporting significant benefits while others show no effect, but it remains one of the prominent herbs for menopause. It is generally considered safe for short-term use.

4. Red Clover

Containing phytoestrogens, plant-based compounds that mimic the effects of estrogen, red clover may help with hormonal balance. Evidence for its effectiveness in reducing hot flashes is limited to moderate, and results may vary depending on individual metabolism.

5. Soy Isoflavones

These are another type of phytoestrogen found in soy products. Evidence is moderate to strong that soy isoflavones can reduce hot flashes, particularly in women who consume high amounts of soy in their diets.

6. Sage Leaf Extract

Sage has been traditionally used for its ability to reduce excessive sweating. A few small human trials suggest that sage leaf extract may help alleviate hot flashes and night sweats, but more research is needed to confirm these findings.

7. Dong Quai

Used in traditional Chinese medicine for hormonal balance and menstrual issues, dong quai has not been supported by robust scientific studies for menopausal symptoms. It may also interact with blood-thinning medications.

8. Chasteberry (Vitex)

Most of the research on chasteberry focuses on its use for PMS symptoms. Its application for menopause is sparse and not well-documented by scientific evidence, although it is believed to help with hormonal balance.

9. Evening Primrose Oil

This oil is high in gamma-linolenic acid (GLA), which may help reduce mild menopausal symptoms like breast tenderness and night sweats. Studies, however, show conflicting results, and its effectiveness is not well-proven.

Supplements for Menopause, Joint Pain, and Stiffness

10. Omega-3 Fatty Acids (Fish Oil)

Omega-3 fatty acids are well-known for their anti-inflammatory properties, which may help reduce joint pain and stiffness. While not directly studied for menopausal joint pain, there is moderate evidence that they benefit overall joint health.

11. Vitamin D

Vitamin D is crucial for calcium absorption and bone health, which is especially important post-menopause when bone density declines rapidly. While there is strong evidence for its role in preventing osteoporosis, its direct benefit for joint pain is limited. This falls under the crucial menopause vitamins to consider for long-term health.

12. Turmeric / Curcumin

Curcumin, the active compound in turmeric, is a powerful anti-inflammatory. Moderate evidence from several human studies suggests that it can reduce pain and stiffness in conditions such as arthritis, making it a promising, albeit non-menopause-specific, supplement for joint health.

13. Magnesium

Magnesium supports muscle and nerve function and can help reduce muscle cramps and tension. While evidence is limited regarding its direct effect on joint pain, it may indirectly support muscle health, improve sleep quality, and enhance mood.

14. Calcium

Calcium is essential for maintaining bone strength, and health organizations widely recommend its intake for post-menopausal women to prevent osteoporosis. The evidence for its benefits is substantial, especially when combined with vitamin D.

15. Collagen Peptides

Collagen is a key component of cartilage and connective tissues. There is moderate evidence from studies on osteoarthritis that collagen peptides can improve joint elasticity and reduce stiffness. More research is needed to confirm these benefits specifically for menopausal joint pain.

16. CBD (Cannabidiol)

Emerging research suggests that CBD may help with chronic pain and inflammation due to its potential anti-inflammatory properties. However, its use is still under research, and it is not FDA-regulated for this purpose.

17. Ginger Extract

Ginger is a natural anti-inflammatory. There is moderate evidence from several trials indicating that ginger extract can help alleviate arthritis symptoms and reduce joint discomfort. It is generally safe for most people.

Supplements for Menopause, Bloating, and Digestion

18. Probiotics

Probiotics are beneficial bacteria that support a healthy gut microbiome. There is strong evidence for their role in improving digestive health and reducing gas and bloating. While not specifically related to menopause, a healthy gut can contribute to overall well-being.

19. Flaxseed

High in fiber and phytoestrogens, flaxseed can support both hormonal balance and digestive regularity. Moderate evidence suggests it can help with bowel movements and may even reduce hot flashes.

20. Peppermint Oil

Known for its ability to soothe the digestive tract, peppermint oil has strong evidence for its effectiveness in relieving symptoms of Irritable Bowel Syndrome (IBS), including gas and bloating. It can be a helpful supplement for menopause-related digestive issues.

21. Digestive Enzymes

These enzymes help break down food, which can reduce bloating and indigestion. Evidence is limited for their use in menopause, but they may be beneficial for individuals who experience sluggish digestion, particularly with high-fat meals.

22. Licorice Root (DGL)

Licorice root can help calm digestive irritation. However, caution is advised as it can raise blood pressure. It is best to use the deglycyrrhizinated (DGL) form, which has had the compound that raises blood pressure removed.

Supplements for Menopause: Itchy Skin and Dryness

23. Hyaluronic Acid (Oral)

Oral hyaluronic acid is gaining popularity for its potential to support skin hydration from within. Early studies are promising and suggest it may increase skin moisture, but more research is needed to confirm its efficacy for menopausal skin dryness.

24. Sea Buckthorn Oil

Rich in omega-7 fatty acids and antioxidants, sea buckthorn oil may help support mucous membranes and skin health. Moderate evidence from some studies supports its benefits for vaginal dryness and overall skin health.

Best Menopause Supplements for Weight Loss and Metabolism

Many women seek the best supplement for perimenopause and menopause to help combat the weight gain that often accompanies hormonal shifts. The following supplements may provide support in this area.

25. Green Tea Extract

Green tea extract contains catechins that may slightly increase fat oxidation and energy expenditure. Moderate evidence suggests that it can have a modest effect on weight loss, but its effectiveness is most pronounced when combined with a healthy diet and regular exercise.

26. Maca Root

Traditionally used in Peru for its energy-boosting and hormonal-balancing properties, maca root is believed to enhance energy, stabilize mood, and reduce sugar cravings. Small studies suggest it may have these benefits, but the evidence is limited.

27. Chromium Picolinate

This mineral plays a role in blood sugar regulation and may help reduce cravings for carbohydrates. However, evidence is mixed, and its effectiveness can vary significantly among individuals.

28. Berberine

Berberine has gained attention for its potential to support insulin sensitivity and fat metabolism. There is moderate to strong evidence that it can aid in blood sugar control and weight management, particularly in individuals with metabolic syndrome.

29. Ashwagandha

As an adaptogen, ashwagandha helps the body manage stress by lowering cortisol levels. Since high cortisol can contribute to weight gain, there is moderate, indirect evidence that ashwagandha may support weight loss by reducing stress.

30. Rhodiola Rosea

Another adaptogen, rhodiola rosea, is known to improve fatigue and may support exercise performance. The benefits for weight loss are indirect, as improved energy and endurance can lead to a more active lifestyle.

Conclusion

Menopause can be a challenging time for many women, and seeking relief through supplements is a common approach. While some menopause supplements may help alleviate symptoms, it’s essential to understand that their effectiveness can vary from person to person. Some options are supported by strong scientific evidence and have helped many women find relief, while others may not have as much research backing them. 

It's crucial to navigate this journey with care and compassion, and consulting a healthcare professional can provide valuable guidance in finding the right option for your unique experience. Remember, there are supportive resources available to help you. Ultimately, finding the best perimenopause supplements often involves a combination of research, personal experimentation, and professional medical advice. 

Always consult a healthcare provider before beginning any new supplement, and remember that lifestyle factors, including diet and exercise, play a crucial role in managing menopausal symptoms. Products like the Mira Fertility Tea, though not explicitly designed for menopause, can provide support through calming herbs that may help with stress, bloating, or sleep.

Frequently Asked Questions

Are natural supplements safe for everyone during menopause?

No, natural supplements are not safe for everyone, and it's wise to be wary. They can have side effects and interact with medications, so it's essential to consult a healthcare provider.

What are the best foods to eat, the best supplements to use, and the most effective exercises to do to maintain strong bones and body following female menopause?

Staying healthy and active after menopause includes prioritizing calcium-rich foods (dairy, leafy greens), using calcium and vitamin D supplements, and engaging in weight-bearing exercises like walking and strength training.

Can natural supplements alone guarantee weight loss during menopause?

No, supplements alone cannot guarantee weight loss. These supplements support a healthy diet and regular exercise, which are the most effective strategies for weight management.

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